Evaluation of the clinical value of automatic online dose restoration for adaptive proton therapy of head and neck cancer.
Radiother Oncol
; 170: 190-197, 2022 05.
Article
en En
| MEDLINE
| ID: mdl-35346754
ABSTRACT
INTRODUCTION:
Intensity modulated proton therapy (IMPT) is highly sensitive to anatomical variations which can cause inadequate target coverage during treatment. This study compares not-adapted (NA) robust plans to two adaptive IMPT methods - a fully-offline adaptive (FOA) and a simplified automatic online adaptive strategy (dose restoration (DR)) to determine the benefit of DR, in head and neck cancer (HNC). MATERIAL/METHODS:
Robustly optimized clinical IMPT doses in planning-CTs (pCTs) were available for a cohort of 10 HNC patients. During robust re-optimization, DR used isodose contours, generated from the clinical dose on pCTs, and patient specific objectives to reproduce the clinical dose in every repeated-CT(rCT). For each rCT(nâ¯=â¯50), NA, DR and FOA plans were robustly evaluated.RESULTS:
An improvement in DVH-metrics and robustness was seen for DR and FOA plans compared to NA plans. For NA plans, 74%(37/50) of rCTs did not fulfill the CTV coverage criteria (D98%>95%Dprescription). DR improved target coverage, target homogeneity and variability on critical risk organs such as the spinal cord. After DR, 52%(26/50) of rCTs met all clinical goals. Because of large anatomical changes and/or inaccurate patient repositioning, 48%(24/50) of rCTs still needed full offline adaptation to ensure an optimal treatment since dose restoration was not able to re-establish the initial plan quality.CONCLUSION:
Robust optimization together with fully-automatized DR avoided offline adaptation in 52% of the cases. Implementation of dose restoration in clinical routine could ensure treatment plan optimality while saving valuable human and material resources to radiotherapy departments.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Radioterapia de Intensidad Modulada
/
Terapia de Protones
/
Neoplasias de Cabeza y Cuello
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Radiother Oncol
Año:
2022
Tipo del documento:
Article