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A mild tetradehydro-Diels-Alder reaction of aryldiyne compounds affords exclusively linear products.
Lu, Yuling; Duan, Xianxian; Chen, Xia; Yao, Meng; Chen, Chunmei; Zhu, Hucheng; Luo, Zengwei; Zhang, Yonghui.
Afiliación
  • Lu Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China. luozengwei@hust.edu.cn.
  • Duan X; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China. luozengwei@hust.edu.cn.
  • Chen X; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China. luozengwei@hust.edu.cn.
  • Yao M; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China. luozengwei@hust.edu.cn.
  • Chen C; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China. luozengwei@hust.edu.cn.
  • Zhu H; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China. luozengwei@hust.edu.cn.
  • Luo Z; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China. luozengwei@hust.edu.cn.
  • Zhang Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China. luozengwei@hust.edu.cn.
Org Biomol Chem ; 20(15): 3174-3182, 2022 04 13.
Article en En | MEDLINE | ID: mdl-35347333
ABSTRACT
The thermal tetradehydro-Diels-Alder (TDDA) reaction for the synthesis of polysubstituted aromatic compounds remains underestimated probably due to the harsh conditions and multiproduct results. Herein, a mild intramolecular TDDA reaction of aryldiyne compounds is presented with linear naphthalenes only, exhibiting good functional group tolerance. The reaction is easy to operate and amenable to multigram-scale synthesis. From the preliminary work, it was found that the mild conditions may be the key to the completely linear product in the reactions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Naftalenos Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Naftalenos Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article