Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways.
Subcell Biochem
; 98: 15-40, 2022.
Article
en En
| MEDLINE
| ID: mdl-35378701
ABSTRACT
Macropinocytosis is an evolutionarily conserved endocytic pathway that mediates the nonselective acquisition of extracellular material via large endocytic vesicles known as macropinosomes. In addition to other functions, this uptake pathway supports cancer cell metabolism through the uptake of nutrients. Cells harboring oncogene or tumor suppressor mutations are known to display heightened macropinocytosis, which confers to the cancer cells the ability to survive and proliferate despite the nutrient-scarce conditions of the tumor microenvironment. Thus, macropinocytosis is associated with cancer malignancy. Macropinocytic uptake can be induced in cancer cells by different stress stimuli, acting as an adaptive mechanism for the cells to resist stresses in the tumor milieu. Here, we review the cellular stresses that are known to promote macropinocytosis, as well as the underlying molecular mechanisms that drive this process.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pinocitosis
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Subcell Biochem
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos