Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma.

Nguyen, Trang T T; Shang, Enyuan; Schiffgens, Salveena; Torrini, Consuelo; Shu, Chang; Akman, Hasan Orhan; Prabhu, Varun V; Allen, Joshua E; Westhoff, Mike-Andrew; Karpel-Massler, Georg; Siegelin, Markus D

Nguyen, Trang T T; Shang, Enyuan; Schiffgens, Salveena; Torrini, Consuelo; Shu, Chang; Akman, Hasan Orhan; Prabhu, Varun V; Allen, Joshua E; Westhoff, Mike-Andrew; Karpel-Massler, Georg; Siegelin, Markus D.

Afiliación

Nguyen TTT; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
Shang E; Department of Biological Sciences, Bronx Community College, City University of New York, Bronx, New York.
Schiffgens S; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
Torrini C; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
Shu C; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
Akman HO; Department of Neurology, Columbia University Medical Center, New York, New York.
Prabhu VV; Chimerix, Inc., Durham, North Carolina.
Allen JE; Chimerix, Inc., Durham, North Carolina.
Westhoff MA; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Karpel-Massler G; Department of Neurosurgery, Ulm University Medical Center, Ulm, Germany.
Siegelin MD; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.

Clin Cancer Res ; 28(9): 1881-1895, 2022 05 02.

Article en En | MEDLINE | ID: mdl-35417530

Asunto(s)

Glioblastoma; Humanos; Apoptosis/genética; Línea Celular Tumoral; Proliferación Celular; Endopeptidasa Clp/genética; Endopeptidasa Clp/metabolismo; Endopeptidasa Clp/uso terapéutico; Glioblastoma/tratamiento farmacológico; Glioblastoma/genética; Glioblastoma/metabolismo; Histona Desacetilasa 1/genética; Inhibidores de Histona Desacetilasas/farmacología; Inhibidores de Histona Desacetilasas/uso terapéutico; Péptido Hidrolasas/genética; Mutaciones Letales Sintéticas; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_brain_nervous_system_cancer Asunto principal: Glioblastoma Límite: Humans Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article

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