[Meta-analysis: effect of chemotherapy on intelligence of children treated for leukemia]. / Meta-analyse: intelligentie van kinderen na chemotherapie wegens leukemie.
Tijdschr Psychiatr
; 64(2): 94-100, 2022.
Article
en Nl
| MEDLINE
| ID: mdl-35420152
ABSTRACT
BACKGROUND:
Leukemia is the most common pediatric malignancy. Acute lymphoblastic leukemia (ALL) is the most commonly observed subtype.AIM:
To assess cognitive functioning in children and adolescents with ALL post-treatment chemotherapy-only (CT-only) or in combination with radiation therapy (CTRT). METHODS We searched in PubMed and PsycINFO (OvidSP). Relevant data were analyzed using statistical program Comprehensive Meta-Analysis (version 2).RESULTS:
44 studies were included in the overall meta-analysis with a total of 5059 patients. A weighted mean IQ of 100.1 (95% CI 99.1-101.0) was found overall after ALL treatment. In subanalyses, we found for CT-only a weighted mean IQ of 100.7 (95% CI 99.5-101.9) and for CTRT-treatment a weighted mean IQ of 98.2 (95%100.7 (95% CI 96.3-100.3). There was no significant difference from the normative control (mean 100.0; SD 15).CONCLUSION:
No significant cognitive sequelae were shown in childhood survivors of leukemia who were exposed to either CT-only or CTRT therapy. Prospective studies are needed with inclusion of pre-and post-treatment IQ measurements, ideally compared to age and socio-economic status matched control groups.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos del Conocimiento
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Adolescent
/
Child
/
Humans
Idioma:
Nl
Revista:
Tijdschr Psychiatr
Año:
2022
Tipo del documento:
Article