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First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization.
Gierse, Robin M; Oerlemans, Rick; Reddem, Eswar R; Gawriljuk, Victor O; Alhayek, Alaa; Baitinger, Dominik; Jakobi, Harald; Laber, Bernd; Lange, Gudrun; Hirsch, Anna K H; Groves, Matthew R.
Afiliación
  • Gierse RM; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, 66123, Saarbrücken, Germany.
  • Oerlemans R; Department of Pharmacy, Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany.
  • Reddem ER; Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
  • Gawriljuk VO; Department of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9700 AV, Groningen, The Netherlands.
  • Alhayek A; Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
  • Baitinger D; Department of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9700 AV, Groningen, The Netherlands.
  • Jakobi H; Department of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9700 AV, Groningen, The Netherlands.
  • Laber B; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100-Santa Angelina, São Carlos, SP, 13563-120, Brazil.
  • Lange G; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, 66123, Saarbrücken, Germany.
  • Hirsch AKH; Department of Pharmacy, Saarland University, Campus Building E8.1, 66123, Saarbrücken, Germany.
  • Groves MR; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E 8.1, 66123, Saarbrücken, Germany.
Sci Rep ; 12(1): 7221, 2022 05 04.
Article en En | MEDLINE | ID: mdl-35508530
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_enfermedades_transmissibles Asunto principal: Mycobacterium tuberculosis Límite: Animals Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_enfermedades_transmissibles Asunto principal: Mycobacterium tuberculosis Límite: Animals Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Alemania