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Using positional information to provide context for biological image analysis with MorphoGraphX 2.0.
Strauss, Sören; Runions, Adam; Lane, Brendan; Eschweiler, Dennis; Bajpai, Namrata; Trozzi, Nicola; Routier-Kierzkowska, Anne-Lise; Yoshida, Saiko; Rodrigues da Silveira, Sylvia; Vijayan, Athul; Tofanelli, Rachele; Majda, Mateusz; Echevin, Emillie; Le Gloanec, Constance; Bertrand-Rakusova, Hana; Adibi, Milad; Schneitz, Kay; Bassel, George W; Kierzkowski, Daniel; Stegmaier, Johannes; Tsiantis, Miltos; Smith, Richard S.
Afiliación
  • Strauss S; Max Planck Institute for Plant Breeding Research, Department of Comparative Development and Genetics, Cologne, Germany.
  • Runions A; Max Planck Institute for Plant Breeding Research, Department of Comparative Development and Genetics, Cologne, Germany.
  • Lane B; Max Planck Institute for Plant Breeding Research, Department of Comparative Development and Genetics, Cologne, Germany.
  • Eschweiler D; John Innes Centre, Norwich Research Park, Norwich, United Kingdom.
  • Bajpai N; Institute of Imaging and Computer Vision, RWTH Aachen University, Aachen, Germany.
  • Trozzi N; Max Planck Institute for Plant Breeding Research, Department of Comparative Development and Genetics, Cologne, Germany.
  • Routier-Kierzkowska AL; Max Planck Institute for Plant Breeding Research, Department of Comparative Development and Genetics, Cologne, Germany.
  • Yoshida S; John Innes Centre, Norwich Research Park, Norwich, United Kingdom.
  • Rodrigues da Silveira S; IRBV, Department of Biological Sciences, University of Montreal, Montreal, Canada.
  • Vijayan A; Max Planck Institute for Plant Breeding Research, Department of Comparative Development and Genetics, Cologne, Germany.
  • Tofanelli R; IRBV, Department of Biological Sciences, University of Montreal, Montreal, Canada.
  • Majda M; Plant Developmental Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
  • Echevin E; Plant Developmental Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
  • Le Gloanec C; Max Planck Institute for Plant Breeding Research, Department of Comparative Development and Genetics, Cologne, Germany.
  • Bertrand-Rakusova H; John Innes Centre, Norwich Research Park, Norwich, United Kingdom.
  • Adibi M; IRBV, Department of Biological Sciences, University of Montreal, Montreal, Canada.
  • Schneitz K; IRBV, Department of Biological Sciences, University of Montreal, Montreal, Canada.
  • Bassel GW; IRBV, Department of Biological Sciences, University of Montreal, Montreal, Canada.
  • Kierzkowski D; Max Planck Institute for Plant Breeding Research, Department of Comparative Development and Genetics, Cologne, Germany.
  • Stegmaier J; Plant Developmental Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
  • Tsiantis M; School of Life Sciences, University of Warwick, Coventry, United Kingdom.
  • Smith RS; IRBV, Department of Biological Sciences, University of Montreal, Montreal, Canada.
Elife ; 112022 05 05.
Article en En | MEDLINE | ID: mdl-35510843
ABSTRACT
Positional information is a central concept in developmental biology. In developing organs, positional information can be idealized as a local coordinate system that arises from morphogen gradients controlled by organizers at key locations. This offers a plausible mechanism for the integration of the molecular networks operating in individual cells into the spatially coordinated multicellular responses necessary for the organization of emergent forms. Understanding how positional cues guide morphogenesis requires the quantification of gene expression and growth dynamics in the context of their underlying coordinate systems. Here, we present recent advances in the MorphoGraphX software (Barbier de Reuille et al., 2015⁠) that implement a generalized framework to annotate developing organs with local coordinate systems. These coordinate systems introduce an organ-centric spatial context to microscopy data, allowing gene expression and growth to be quantified and compared in the context of the positional information thought to control them.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procesamiento de Imagen Asistido por Computador / Programas Informáticos Idioma: En Revista: Elife Año: 2022 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procesamiento de Imagen Asistido por Computador / Programas Informáticos Idioma: En Revista: Elife Año: 2022 Tipo del documento: Article País de afiliación: Alemania
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