EFFECT OF IMUNOFAN INFLUENCE ON THE STRUCTURE OF THE TESTES, HORMONAL AND CYTOKINE PROFILE OF IMMATURE EXPERIMENTAL ANIMALS.

OBJECTIVE: The aim: It was the establishing the features of changes in the structure of the testes of experimental animals, as well as immunological, hormonal and cytokine parameters of blood plasma during stimulation. PATIENTS AND METHODS: Materials and methods: The study was carried out on 60 white male immature rats. Imunofan was used at a dosage of 50 υg. The organs were weighed, the relative mass was calculated, and the linear dimensions were determined. The morphometriv parameters of the epitheliospermatogenic layer were measured. The number of supporting cells and interstitial endocrinocytes was counted, as well as the volume of cell nuclei. The level of reproductive hormones in the plasma and the concentration of cytokines were determined. RESULTS: Results: The results obtained indicate the development of readaptation processes in the testes after the use of the Imunofan against the background of environmental immunosuppression. The ability of the drug to stimulate the production of cytokines and hormones normalizes the function of immunocompetent cells, which is manifested in the stabilization of the immune homeostasis of the testes. CONCLUSION: Conclusions: In response to the immunostimulating effect of Imunofan, a pronounced reaction is observed on the part of the testes of immature animals, which is due to the sensitivity of morphogenetic processes in the organ to external influences and the formation of mechanisms of their regulation, characteristic of this period of ontogenesis.