The role of progesterone receptor membrane component (PGRMC) in the endometrium.
Steroids
; 184: 109040, 2022 08.
Article
en En
| MEDLINE
| ID: mdl-35526781
ABSTRACT
PGRMC is a non-classical receptor that mediates the non-genomic responses to progesterone and is distributed in different subcellular compartments. PGRMC belongs to the membrane-associated progesterone receptor (MAPR) family. Two PGRMC subtypes (PGRMC1 and PGRMC2) have been characterized, and both are expressed in the human endometrium. PGRMC expression is differentially regulated during the menstrual cycle in the human endometrium. Although PGRMC1 is predominantly expressed in the proliferative phase and PGRMC2 in the secretory phase, this expression changes in pathologies such as endometriosis, in which PGRMC2 expression considerably decreases, promoting progesterone resistance. In endometrial cancer, PGRMC1 is overexpressed, its activation induces tumors growth, and confers chemoresistance in the presence of progesterone. Thus, PGRMCs play a key role in progesterone actions in the endometrium.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Uterinas
/
Receptores de Progesterona
/
Endometrio
/
Proteínas de la Membrana
Límite:
Female
/
Humans
Idioma:
En
Revista:
Steroids
Año:
2022
Tipo del documento:
Article
País de afiliación:
México