Preparation of prolinamide with adamantane for aldol reaction catalysis in brine and separation using a poly(AN-MA-ß-CD) nanofibrous film via host-guest interaction.
RSC Adv
; 8(50): 28376-28385, 2018 Aug 07.
Article
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| MEDLINE
| ID: mdl-35542465
ABSTRACT
Prolinamides with double-H potential were prepared and employed as organocatalysts in asymmetric aldol reactions. The catalyst with adamantane showed improved catalytic activity, which was further enhanced by using brine as the solvent. A series of aldol reactions in brine at 0 °C provided good yields (up to 98%) with high diastereoselectivities (>99 1) and enantioselectivities (>99%). The prepared catalyst was adsorbed by a nanofibrous film of poly(AN-MA-ß-CD) via host-guest interaction in the reaction system. The catalyst was separated from the film by applying ultrasound, with a total recovery of 96.2%. The catalyst was reused up to five times without a significant change in diastereoselectivity and enantioselectivity.
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01-internacional
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MEDLINE
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En
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RSC Adv
Año:
2018
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Article