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MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.
Hayashi, Yasutaka; Kawabata, Kimihito C; Tanaka, Yosuke; Uehara, Yasufumi; Mabuchi, Yo; Murakami, Koichi; Nishiyama, Akira; Kiryu, Shigeru; Yoshioka, Yusuke; Ota, Yasunori; Sugiyama, Tatsuki; Mikami, Keiko; Tamura, Moe; Fukushima, Tsuyoshi; Asada, Shuhei; Takeda, Reina; Kunisaki, Yuya; Fukuyama, Tomofusa; Yokoyama, Kazuaki; Uchida, Tomoyuki; Hagihara, Masao; Ohno, Nobuhiro; Usuki, Kensuke; Tojo, Arinobu; Katayama, Yoshio; Goyama, Susumu; Arai, Fumio; Tamura, Tomohiko; Nagasawa, Takashi; Ochiya, Takahiro; Inoue, Daichi; Kitamura, Toshio.
Afiliación
  • Hayashi Y; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan; Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Minatojimaminami-machi, Chuo
  • Kawabata KC; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan; Division of Hematology/Medical Oncology, Department of Medicine, Weill-Cornell Medical College, Cornell University, NY 10021, USA.
  • Tanaka Y; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Uehara Y; Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan.
  • Mabuchi Y; Department of Biochemistry and Biophysics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
  • Murakami K; Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama 236-0043, Japan; Advanced Medical Research Center, Yokohama City University, Yokohama 236-0043, Japan.
  • Nishiyama A; Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama 236-0043, Japan.
  • Kiryu S; Department of Radiology, International University of Health and Welfare Narita Hospital, Chiba 286-8686, Japan.
  • Yoshioka Y; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo 160-0023, Japan.
  • Ota Y; Department of Pathology, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
  • Sugiyama T; Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
  • Mikami K; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Tamura M; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan; Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo 108-8639, Japan.
  • Fukushima T; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Asada S; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Takeda R; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Kunisaki Y; Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan.
  • Fukuyama T; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Yokoyama K; Department of Hematology/Oncology, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
  • Uchida T; Department of Hematology, Eiju General Hospital, Tokyo 110-8645, Japan.
  • Hagihara M; Department of Hematology, Eiju General Hospital, Tokyo 110-8645, Japan.
  • Ohno N; Department of Hematology, Kanto Rosai Hospital, Kawasaki 211-8510, Japan.
  • Usuki K; Department of Hematology, NTT Medical Center Tokyo, Tokyo 141-8625, Japan.
  • Tojo A; Department of Hematology/Oncology, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
  • Katayama Y; Hematology, Kobe University Hospital, Kobe 650-0017, Japan.
  • Goyama S; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan; Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo 108-8639, Japan.
  • Arai F; Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
  • Tamura T; Department of Biochemistry and Biophysics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan; Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama 236-0043, Japan.
  • Nagasawa T; Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
  • Ochiya T; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo 160-0023, Japan.
  • Inoue D; Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Minatojimaminami-machi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: d-inoue@fbri.org.
  • Kitamura T; Division of Cellular Therapy, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address: kitamura@ims.u-tokyo.ac.jp.
Cell Rep ; 39(6): 110805, 2022 05 10.
Article en En | MEDLINE | ID: mdl-35545056
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Células Madre Mesenquimatosas / Vesículas Extracelulares Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Rep Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Células Madre Mesenquimatosas / Vesículas Extracelulares Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Rep Año: 2022 Tipo del documento: Article