Structural modification of oridonin <i>via</i> DAST induced rearrangement.

Luo, Dong-Dong; Peng, Kai; Yang, Jia-Yu; Piyachaturawat, Pawinee; Saengsawang, Witchuda; Ao, Lei; Zhao, Wan-Zhou; Tang, Yu; Wan, Sheng-Biao

Structural modification of oridonin via DAST induced rearrangement.

Luo, Dong-Dong; Peng, Kai; Yang, Jia-Yu; Piyachaturawat, Pawinee; Saengsawang, Witchuda; Ao, Lei; Zhao, Wan-Zhou; Tang, Yu; Wan, Sheng-Biao.

Afiliación

Luo DD; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China Yushan Road 5 Qingdao 266003 China biaowan@ouc.edu.cn tangyu@ouc.edu.cn +86-
Peng K; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China Yushan Road 5 Qingdao 266003 China biaowan@ouc.edu.cn tangyu@ouc.edu.cn +86-
Yang JY; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China Yushan Road 5 Qingdao 266003 China biaowan@ouc.edu.cn tangyu@ouc.edu.cn +86-
Piyachaturawat P; Department of Physiology, Faculty of Science, Mahidol University Bangkok 10400 Thailand.
Saengsawang W; Department of Physiology, Faculty of Science, Mahidol University Bangkok 10400 Thailand.
Ao L; The Nanjing Han & Zaenker Cancer Institute (NHZCI), Nanjing OGpharma Co. Ltd. Nanjing 210036 China.
Zhao WZ; The Nanjing Han & Zaenker Cancer Institute (NHZCI), Nanjing OGpharma Co. Ltd. Nanjing 210036 China.
Tang Y; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China Yushan Road 5 Qingdao 266003 China biaowan@ouc.edu.cn tangyu@ouc.edu.cn +86-
Wan SB; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China Yushan Road 5 Qingdao 266003 China biaowan@ouc.edu.cn tangyu@ouc.edu.cn +86-

RSC Adv ; 8(52): 29548-29554, 2018 Aug 20.

Article en En | MEDLINE | ID: mdl-35547324

ABSTRACT

ABSTRACT

A simple and efficient protocol was developed for the syntheses of oridonin analogues, i.e. 6,20-epoxy ent-kaurane diterpenoid analogues from oridonin via diethylaminosulfur trifluoride (DAST) promoted rearrangement, most of which exhibited superior anticancer activities compared with their precursor.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2018 Tipo del documento: Article