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Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain.
Smith, Jacob G; Sato, Tomoki; Shimaji, Kohei; Koronowski, Kevin B; Petrus, Paul; Cervantes, Marlene; Kinouchi, Kenichiro; Lutter, Dominik; Dyar, Kenneth A; Sassone-Corsi, Paolo.
Afiliación
  • Smith JG; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA. Electronic address: jacob.smith@uci.edu.
  • Sato T; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
  • Shimaji K; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
  • Koronowski KB; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
  • Petrus P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
  • Cervantes M; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
  • Kinouchi K; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA; Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Lutter D; German Center for Diabetes Research (DZD), Neuherberg, Germany; Computational Discovery Research, Institute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, Neuherberg, Germany.
  • Dyar KA; German Center for Diabetes Research (DZD), Neuherberg, Germany; Metabolic Physiology, Institute for Diabetes and Cancer, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
  • Sassone-Corsi P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
Life Sci ; 303: 120601, 2022 Aug 15.
Article en En | MEDLINE | ID: mdl-35561749
ABSTRACT
The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_zoonosis Asunto principal: Microbioma Gastrointestinal / Antibacterianos Límite: Animals Idioma: En Revista: Life Sci Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_zoonosis Asunto principal: Microbioma Gastrointestinal / Antibacterianos Límite: Animals Idioma: En Revista: Life Sci Año: 2022 Tipo del documento: Article