Hypertriglyceridaemia in adolescents may have serious complications.
S Afr Med J
; 112(5): 307-312, 2022 04 29.
Article
en En
| MEDLINE
| ID: mdl-35587241
ABSTRACT
Acute pancreatitis is an often-overlooked cause of acute abdominal pain in children and adolescents. Severe hypertriglyceridaemia is an important cause of recurrent acute pancreatitis. Monogenic causes of hypertriglyceridaemia, such as familial chylomicronaemia caused by lipoprotein lipase deficiency, are more frequently encountered in children and adolescents, but remain rare. Polygenic hypertriglyceridaemia is more common, but may require a precipitant before manifesting. With the global increase in obesity and type 2 diabetes, secondary causes of hypertriglyceridaemia in children and adolescents are increasing. We report two cases of severe hypertriglyceridaemia and pancreatitis in adolescent females. Hypertriglyceridaemia improved markedly with restriction of dietary fat. An inhibitor to lipoprotein lipase was found to be the cause in one patient, while in the other limited genetic investigation excluded chylomicronaemia owing to deficiency of lipoprotein lipase, its activators and processing proteins.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pancreatitis
/
Hipertrigliceridemia
/
Diabetes Mellitus Tipo 2
/
Hiperlipoproteinemia Tipo I
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Adolescent
/
Female
/
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
S Afr Med J
Año:
2022
Tipo del documento:
Article
País de afiliación:
Sudáfrica