Association of physical activity with high-density lipoprotein functionality in a population-based cohort: the REGICOR study.
Rev Esp Cardiol (Engl Ed)
; 76(2): 86-93, 2023 Feb.
Article
en En, Es
| MEDLINE
| ID: mdl-35597758
ABSTRACT
INTRODUCTION AND OBJECTIVES:
To determine the dose-response association between current and past leisure-time physical activity (LTPA), total and at different intensities, and high-density lipoprotein (HDL) functionality parameters.METHODS:
Study participants (n=642) were randomly drawn from a large population-based survey. Mean age of the participants was 63.2 years and 51.1% were women. The analysis included data from a baseline and a follow-up visit (median follow-up, 4 years). LTPA was assessed using validated questionnaires at both visits. Two main HDL functions were assessed cholesterol efflux capacity and HDL antioxidant capacity, at the follow-up visit. Linear regression and linear additive models were used to assess the linear and nonlinear association between LTPA and HDL functionality.RESULTS:
Total LTPA at follow-up showed an inverse and linear relationship between 0 and 400 METs x min/d with HDL antioxidant capacity (regression coefficient [beta] -0.022; 95%CI, -0.030, -0.013), with a plateau above this threshold. The results were similar for moderate (beta -0.028; 95%CI, -0.049, -0.007) and vigorous (beta -0.025; 95%CI, -0.043, -0.007), but not for light-intensity LTPA. LTPA at follow-up was not associated with cholesterol efflux capacity. Baseline LTPA was not associated with any of the HDL functionality parameters analyzed.CONCLUSIONS:
Current moderate and vigorous LTPA showed a nonlinear association with higher HDL antioxidant capacity. Maximal benefit was observed with low-intermediate doses of total LTPA (up to 400 METs x min/d). Our results agree with current recommendations for moderate-vigorous LTPA practice and suggest an association between PA and HDL functionality in the general population.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lipoproteínas HDL
/
Antioxidantes
Tipo de estudio:
Etiology_studies
/
Guideline
/
Risk_factors_studies
Límite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
/
Es
Revista:
Rev Esp Cardiol (Engl Ed)
Año:
2023
Tipo del documento:
Article
País de afiliación:
España