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Comparison of ANP and BNP Granular Density in Atria of Rats After Physiological and Pathological Hypertrophy.
Agostinucci, Kevin; Manfredi, Thomas G; Cosmas, Arthur C; Vetter, Frederick J; Engle, Steven K.
Afiliación
  • Agostinucci K; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota, USA.
  • Manfredi TG; Department of Kinesiology, University of Rhode Island, Kingston, Rhode Island, USA.
  • Cosmas AC; Department of Kinesiology, University of Rhode Island, Kingston, Rhode Island, USA.
  • Vetter FJ; Select Medical Sports Medicine and Outpatient Rehabilitation, West Hartford, Connecticut, USA.
  • Engle SK; Department of Electrical, Computer and Biomedical Engineering, University of Rhode Island, Kingston, Rhode Island, USA.
Toxicol Pathol ; 50(4): 497-506, 2022 06.
Article en En | MEDLINE | ID: mdl-35608026
ABSTRACT
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones located in atria granules. Both peptides respond to cardiac pressure and volume dynamics and accordingly serve as translation biomarkers for the clinical treatment of heart failure. Serum ANP and BNP play central secretary roles in blood pressure and cardiac output regulation and have proven utility as differential biomarkers of cardiovascular proficiency and drug-induced maladaptation, yet both peptides are impervious to exercise-induced hypertrophy. We employed immunoelectron microscopy to examine the effects of 28 days of chronic swim exercise or administration of a PPARγ agonist on atrial granules and their stored natriuretic peptides in Sprague Dawley rats. Chronic swimming and drug treatment both resulted in a 15% increase in heart weight compared with controls, with no treatment effects on perinuclear granule area in the left atria (LAs). Drug treatment resulted in larger size granules with greater BNP density in the right atria. Comparing swimming and PPARγ agonist treatment effects on ANPBNP granule density ratios between atrial chambers revealed a shift toward a greater proportion of ANP than BNP in LAs of swim-trained rats. These data suggest a distinction in the population of ANP and BNP after chronic swim or PPARγ that makes it a novel metric for the differentiation of pathological and physiological hypertrophy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor Natriurético Atrial / Péptido Natriurético Encefálico Límite: Animals Idioma: En Revista: Toxicol Pathol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor Natriurético Atrial / Péptido Natriurético Encefálico Límite: Animals Idioma: En Revista: Toxicol Pathol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
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