An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment.
ACS Infect Dis
; 8(6): 1107-1115, 2022 06 10.
Article
en En
| MEDLINE
| ID: mdl-35652513
ABSTRACT
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies CD as the most prevalent of poverty-promoting neglected tropical diseases, the most important parasitic one, and the third most infectious disease in Latin America. Currently, CD is a global public health issue that affects 6-8 million people. However, the current approved treatments are limited to two nitroheterocyclic drugs developed more than 50 years ago. Many efforts have been made in recent decades to find new therapies, but our limited understanding of the infection process, pathology development, and long-term nature of this disease has made it impossible to develop new drugs, effective treatment, or vaccines. This Review aims to provide a comprehensive update on our understanding of the current life cycle, new morphological forms, and genetic diversity of T. cruzi, as well as identify intervention points in the life cycle where new drugs and treatments could achieve a parasitic cure.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
3_ND
Problema de salud:
2_cobertura_universal
/
3_chagas_disease
/
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Trypanosoma cruzi
/
Enfermedad de Chagas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
ACS Infect Dis
Año:
2022
Tipo del documento:
Article
País de afiliación:
España