Lymphatic Clearance and Pump Function.
Cold Spring Harb Perspect Med
; 13(2)2023 02 01.
Article
en En
| MEDLINE
| ID: mdl-35667711
ABSTRACT
Lymphatic vessels have an active role in draining excess interstitial fluid from organs and serving as conduits for immune cell trafficking to lymph nodes. In the central circulation, the force needed to propel blood forward is generated by the heart. In contrast, lymphatic vessels rely on intrinsic vessel contractions in combination with extrinsic forces for lymph propulsion. The intrinsic pumping features phasic contractions generated by lymphatic smooth muscle. Periodic, bicuspid valves composed of endothelial cells prevent backflow of lymph. This work provides a brief overview of lymph transport, including initial lymph formation along with cellular and molecular mechanisms controlling lymphatic vessel pumping.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vasos Linfáticos
/
Sistema Linfático
Límite:
Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos