Low frequency vibrating magnetic field-triggered magnetic microspheres with a nanoflagellum-like surface for cancer therapy.
J Nanobiotechnology
; 20(1): 316, 2022 Jul 06.
Article
en En
| MEDLINE
| ID: mdl-35794559
ABSTRACT
BACKGROUND:
The magneto-mechanical force killing cancer cells is an interesting and important strategy for cancer therapy.RESULTS:
Novel magnetic microspheres composed of a Fe3O4 nanocore, a bovine serum albumin (BSA) matrix, and a rod-like SiO2 nanoshell, which had flagellum-like surface for force-mediated cancer therapy were developed. One such magnetic microsphere (Fe3O4/BSA/rSiO2) at a cancer cell (not leave the cell surface) under a low frequency vibrating magnetic field (VMF) could generate 6.17 pN force. Interestingly, this force could induce cancer cell to generate reactive oxygen species (ROS). The force and force-induced ROS could kill cancer cells. The cell killing efficiency of Fe3O4/BSA/rSiO2 exposed to a VMF was enhanced with increasing silica nanorod length, and the microspheres with straight nanorods exhibited stronger cell killing ability than those with curled nanorods. Fe3O4/BSA/rSiO2 triggered by a VMF could efficiently inhibit mouse tumor growth, while these microspheres without a VMF had no significant effect on the cell cycle distribution, cell viability, tumor growth, and mouse health.CONCLUSIONS:
These microspheres with unique morphological characteristics under VMF have great potential that can provide a new platform for treating solid tumors at superficial positions whether with hypoxia regions or multidrug resistance.Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dióxido de Silicio
/
Neoplasias
Límite:
Animals
Idioma:
En
Revista:
J Nanobiotechnology
Año:
2022
Tipo del documento:
Article