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Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease.
Dedrick, Rebekah M; Freeman, Krista G; Nguyen, Jan A; Bahadirli-Talbott, Asli; Cardin, Mitchell E; Cristinziano, Madison; Smith, Bailey E; Jeong, Soowan; Ignatius, Elisa H; Lin, Cheng Ting; Cohen, Keira A; Hatfull, Graham F.
Afiliación
  • Dedrick RM; Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Freeman KG; Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Nguyen JA; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Bahadirli-Talbott A; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Cardin ME; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Cristinziano M; Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Smith BE; Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Jeong S; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Ignatius EH; Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Lin CT; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Cohen KA; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Hatfull GF; Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Open Forum Infect Dis ; 9(7): ofac194, 2022 Jul.
Article en En | MEDLINE | ID: mdl-35794944
ABSTRACT
An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak sputum neutralization may have limited the outcomes, but phage resistance was not a contributing factor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos