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Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin.
Krzeszewski, Maciej; Modrzycka, Sylwia; Bousquet, Manon H E; Jacquemin, Denis; Drag, Marcin; Gryko, Daniel T.
Afiliación
  • Krzeszewski M; Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.
  • Modrzycka S; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wybrezeze Wyspianskiego 27, Wroclaw 50-370, Poland.
  • Bousquet MHE; CEISAM UMR CNRS 6230, Nantes University, Nantes 44000, France.
  • Jacquemin D; CEISAM UMR CNRS 6230, Nantes University, Nantes 44000, France.
  • Drag M; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wybrezeze Wyspianskiego 27, Wroclaw 50-370, Poland.
  • Gryko DT; Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.
Org Lett ; 24(30): 5602-5607, 2022 08 05.
Article en En | MEDLINE | ID: mdl-35863755
ABSTRACT
The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide sequence, a reactive warhead, and the brightest green-emitting fluorophore displays impressive performance for thrombin protease detection in a newly constructed series of 1,8-naphthalimides.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombina / Naftalimidas Tipo de estudio: Diagnostic_studies Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Polonia
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombina / Naftalimidas Tipo de estudio: Diagnostic_studies Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Polonia