Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.

Matsuo, Taira; Komori, Rie; Nakatani, Minami; Ochi, Shiori; Yokota-Nakatsuma, Aya; Matsumoto, Junichi; Takata, Fuyuko; Dohgu, Shinya; Ishihara, Yasuhiro; Itoh, Kouichi

Matsuo, Taira; Komori, Rie; Nakatani, Minami; Ochi, Shiori; Yokota-Nakatsuma, Aya; Matsumoto, Junichi; Takata, Fuyuko; Dohgu, Shinya; Ishihara, Yasuhiro; Itoh, Kouichi.

Afiliación

Matsuo T; Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki 769-2193, Japan.
Komori R; Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki 769-2193, Japan.
Nakatani M; Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki 769-2193, Japan.
Ochi S; Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki 769-2193, Japan.
Yokota-Nakatsuma A; Laboratory of Immunology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki 769-2193, Japan.
Matsumoto J; Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Takata F; Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Dohgu S; Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Ishihara Y; Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8521, Japan.
Itoh K; Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki 769-2193, Japan.

Int J Mol Sci ; 23(14)2022 Jul 12.

Article en En | MEDLINE | ID: mdl-35887020

Asunto(s)

Anticonvulsivantes; Encefalitis; Levetiracetam; Estado Epiléptico; Animales; Anticonvulsivantes/farmacología; Anticonvulsivantes/uso terapéutico; Citocinas/inmunología; Modelos Animales de Enfermedad; Encefalitis/inducido químicamente; Encefalitis/inmunología; Encefalitis/prevención & control; Levetiracetam/farmacología; Levetiracetam/uso terapéutico; Ratones; Monocitos/inmunología; Neutrófilos/inmunología; Pilocarpina/toxicidad; Proteoma; Estado Epiléptico/tratamiento farmacológico; Estado Epiléptico/etiología; Estado Epiléptico/inmunología

Palabras clave

epileptogenesis; levetiracetam; neuroinflammation; neutrophil

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_doencas_nao_transmissiveis Asunto principal: Estado Epiléptico / Encefalitis / Levetiracetam / Anticonvulsivantes Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Japón

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