Safety and Efficacy of Low-dose Prasugrel in the Endovascular Treatment of Unruptured Aneurysms in the Elders (≥â¯75 Years).
Clin Neuroradiol
; 33(1): 179-186, 2023 Mar.
Article
en En
| MEDLINE
| ID: mdl-35900387
ABSTRACT
PURPOSE:
The effectiveness and safety of low-dose prasugrel (PSG) premedication for endovascular treatment of unruptured intracranial aneurysms (UIAs) have been widely reported. In this study, we evaluated the clinical outcomes of elders patients (≥â¯75 years) treated with PSG.METHODS:
A total of 200 patients with 209 UIAs who were administered PSG as premedication (20â¯mg loading and 5â¯mg maintenance with 100â¯mg aspirin) between March 2018 and December 2021 were retrospectively enrolled. Among them, 39 patients were aged 75 years or over (elders group), and 161 patients were aged under 75 years (control group). Patients' clinical data were collected, and outcomes were compared between the two groups.RESULTS:
Of the 200 patients with PSG, 9 cases (4.5%) had overall complications (7 ischemic, 2 hemorrhagic). In the comparison between the elders group and the control group, no significant differences were observed in the overall complication rates (elders group vs. control group; 2.6% vs. 5.0%, Pâ¯= 1.00). Moreover, the rates of poor clinical outcome were comparable (2.6% vs. 1.2%, Pâ¯= 0.48). The subgroup analysis of patients with stent-assisted procedures revealed no significant differences in complication rates (0% vs. 1.6%, Pâ¯= 1.00) or poor clinical outcomes (0% vs. 0%, Pâ¯= 1.00) during maintenance with aspirin 100â¯mg or PSG 5â¯mg.CONCLUSION:
The complication rates in the elders treated with low-dose PSG premedication were similar to those in the control. Low-dose PSG premedication could be prescribed without any additional risk for the endovascular treatment of UIAs in elders patients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aneurisma Intracraneal
/
Embolización Terapéutica
/
Procedimientos Endovasculares
Límite:
Aged
/
Humans
Idioma:
En
Revista:
Clin Neuroradiol
Asunto de la revista:
NEUROLOGIA
/
RADIOLOGIA
Año:
2023
Tipo del documento:
Article