Effect of SKF525-A on the glutathione-conjugating enzyme system and on liver toxicity.
Toxicol Lett
; 36(3): 275-80, 1987 May.
Article
en En
| MEDLINE
| ID: mdl-3590222
ABSTRACT
SKF525-A given intraperitoneally (50 mg/kg body weight) to Sprague-Dawley rats in a single dose promoted a significant reduction in cytosolic glutathione S-transferase (GST) activities 0.5 and 1 h after injection. There was no decrease in liver non-protein sulfhydryls (NPSH) 0.5, 1 and 24 h after injection. Serum activities of glutamic pyruvic transaminase (GPT), sorbitol dehydrogenase (SDH), glutamic oxaloacetic transaminase (GOT) and glutamate dehydrogenase (GLDH) increased 1.8-, 2.9-, 3.8- and 41.2-fold respectively 8 h after injection, and the increased serum enzyme activities were maintained for up to 24 h. On the basis of these results, SKF525-A-induced blood manifestations of liver toxicity and decrease in GST activities may be regarded as confusing factors in the evaluation of the oxidative metabolism of compounds in Sprague-Dawley rats.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proadifeno
/
Glutatión Transferasa
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Toxicol Lett
Año:
1987
Tipo del documento:
Article