Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis.

Ghosh, Sweta; Singh, Rajbir; Vanwinkle, Zachary Matthew; Guo, Haixun; Vemula, Praveen Kumar; Goel, Ajay; Haribabu, Bodduluri; Jala, Venkatakrishna Rao

Ghosh, Sweta; Singh, Rajbir; Vanwinkle, Zachary Matthew; Guo, Haixun; Vemula, Praveen Kumar; Goel, Ajay; Haribabu, Bodduluri; Jala, Venkatakrishna Rao.

Afiliación

Ghosh S; Department of Microbiology and Immunology, Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA.
Singh R; Department of Microbiology and Immunology, Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA.
Vanwinkle ZM; Department of Microbiology and Immunology, Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA.
Guo H; Department of Radiology, Center for Predictive Medicine, University of Louisville, Louisville, KY, USA.
Vemula PK; Institute for Stem Cell Biology and Regenerative Medicine (inStem), GKVK campus, Bangalore, Karnataka 560065, India.
Goel A; Department of Molecular Diagnostics and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Haribabu B; Department of Microbiology and Immunology, Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA.
Jala VR; Department of Microbiology and Immunology, Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA.

Theranostics ; 12(12): 5574-5595, 2022.

Article en En | MEDLINE | ID: mdl-35910798

Asunto(s)

Neoplasias del Colon; Resistencia a Antineoplásicos; Fluorouracilo; Proteína Forkhead Box M1; Proteína Forkhead Box O3; Microbioma Gastrointestinal; Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2; Animales; Antimetabolitos Antineoplásicos/metabolismo; Azoximetano; Línea Celular Tumoral/efectos de los fármacos; Línea Celular Tumoral/metabolismo; Neoplasias del Colon/tratamiento farmacológico; Neoplasias del Colon/genética; Neoplasias del Colon/metabolismo; Neoplasias del Colon/patología; Cumarinas/metabolismo; Resistencia a Antineoplásicos/genética; Resistencia a Antineoplásicos/fisiología; Fluorouracilo/metabolismo; Fluorouracilo/farmacología; Fluorouracilo/uso terapéutico; Proteína Forkhead Box M1/genética; Proteína Forkhead Box M1/metabolismo; Proteína Forkhead Box O3/genética; Proteína Forkhead Box O3/metabolismo; Microbioma Gastrointestinal/genética; Microbioma Gastrointestinal/fisiología; Humanos; Ratones; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo

Palabras clave

5-Fluorouracil; Chemoresistant colon cancer; Chemosensitization; FOXO3-FOXM1 axis; Microbial metabolite; Urolithin A; drug transporters

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_zoonosis Asunto principal: Neoplasias del Colon / Resistencia a Antineoplásicos / Fluorouracilo / Microbioma Gastrointestinal / Proteína Forkhead Box M1 / Proteína Forkhead Box O3 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Theranostics Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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