Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture.

Guy, Collette S; Tomás, Ruben M F; Tang, Qiao; Gibson, Matthew I; Fullam, Elizabeth

Guy, Collette S; Tomás, Ruben M F; Tang, Qiao; Gibson, Matthew I; Fullam, Elizabeth.

Afiliación

Guy CS; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK. e.fullam@warwick.ac.uk.
Tomás RMF; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Tang Q; Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
Gibson MI; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Fullam E; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.

Chem Commun (Camb) ; 58(67): 9361-9364, 2022 Aug 18.

Article en En | MEDLINE | ID: mdl-35917119

ABSTRACT

ABSTRACT

Dimeric boronic acids kill Mycobacterium tuberculosis (Mtb) by targeting mycobacterial specific extracellular glycans, removing the requirement for a therapeutic agent to permeate the complex cell envelope. Here we report the successful development and use of new 'clickable' boronic acid probes as a powerful method to enable the direct detection and visualisation of this unique class of cell-surface targeting antitubercular agents.

Asunto(s)

Ácidos Borónicos; Mycobacterium tuberculosis; Antituberculosos/metabolismo; Antituberculosos/farmacología; Ácidos Borónicos/metabolismo; Ácidos Borónicos/farmacología; Polímeros/metabolismo; Polisacáridos/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_tuberculosis Asunto principal: Ácidos Borónicos / Mycobacterium tuberculosis Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido

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