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Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy.
Kwon, Nahyun; Kim, Kwang H; Park, Sinyoung; Cho, Yejin; Park, Eun-Yeong; Lim, Junha; Çetindere, Seda; Tümay, Süreyya Oguz; Kim, Won Jong; Li, Xingshu; Nam, Ki Taek; Kim, Chulhong; Yesilot, Serkan; Yoon, Juyoung.
Afiliación
  • Kwon N; Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 03760, Republic of Korea.
  • Kim KH; Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
  • Park S; Departments of Electrical Engineering, Mechanical Engineering, Convergence IT Engineering, and Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic
  • Cho Y; Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
  • Park EY; Departments of Electrical Engineering, Mechanical Engineering, Convergence IT Engineering, and Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic
  • Lim J; Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
  • Çetindere S; Department of Chemistry, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey.
  • Tümay SO; Department of Chemistry, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey.
  • Kim WJ; Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
  • Li X; College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China. Electronic address: xingshuli@fzu.edu.cn.
  • Nam KT; Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea. Electronic address: kitaek@yuhs.ac.
  • Kim C; Departments of Electrical Engineering, Mechanical Engineering, Convergence IT Engineering, and Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic
  • Yesilot S; Department of Chemistry, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey. Electronic address: yesil@gtu.edu.tr.
  • Yoon J; Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 03760, Republic of Korea. Electronic address: jyoon@ewha.ac.kr.
Biosens Bioelectron ; 216: 114612, 2022 Nov 15.
Article en En | MEDLINE | ID: mdl-35952434
Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, 'safe' fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas Biosensibles / Nanopartículas / Técnicas Fotoacústicas / Neoplasias Límite: Animals Idioma: En Revista: Biosens Bioelectron Asunto de la revista: BIOTECNOLOGIA Año: 2022 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas Biosensibles / Nanopartículas / Técnicas Fotoacústicas / Neoplasias Límite: Animals Idioma: En Revista: Biosens Bioelectron Asunto de la revista: BIOTECNOLOGIA Año: 2022 Tipo del documento: Article