Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections.

Hawryluk, Natalie; Robinson, Dale; Shen, Yixing; Kyne, Graham; Bedore, Matthew; Menon, Sanjay; Canan, Stacie; von Geldern, Thomas; Townson, Simon; Gokool, Suzanne; Ehrens, Alexandra; Koschel, Marianne; Lhermitte-Vallarino, Nathaly; Martin, Coralie; Hoerauf, Achim; Hernandez, Geraldine; Dalvie, Deepak; Specht, Sabine; Hübner, Marc Peter; Scandale, Ivan

Hawryluk, Natalie; Robinson, Dale; Shen, Yixing; Kyne, Graham; Bedore, Matthew; Menon, Sanjay; Canan, Stacie; von Geldern, Thomas; Townson, Simon; Gokool, Suzanne; Ehrens, Alexandra; Koschel, Marianne; Lhermitte-Vallarino, Nathaly; Martin, Coralie; Hoerauf, Achim; Hernandez, Geraldine; Dalvie, Deepak; Specht, Sabine; Hübner, Marc Peter; Scandale, Ivan.

Afiliación

Hawryluk N; Bristol Myers Squibb, San Diego, California 92121, United States.
Robinson D; Bristol Myers Squibb, San Diego, California 92121, United States.
Shen Y; Bristol Myers Squibb, San Diego, California 92121, United States.
Kyne G; Zoetis, Kalamazoo, Michigan 49001, United States.
Bedore M; Zoetis, Kalamazoo, Michigan 49001, United States.
Menon S; Zoetis, Kalamazoo, Michigan 49001, United States.
Canan S; Bristol Myers Squibb, San Diego, California 92121, United States.
von Geldern T; Embedded Consulting, Richmond, Illinois 60071, United States.
Townson S; Northwick Park Institute for Medical Research, London HA1 3UJ, UK.
Gokool S; Northwick Park Institute for Medical Research, London HA1 3UJ, UK.
Ehrens A; Institute for Medical Microbiology, Immunology & Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Koschel M; German Center for Infection Research (DZIF), partner site Bonn-Cologne, 53127 Bonn, Germany.
Lhermitte-Vallarino N; Institute for Medical Microbiology, Immunology & Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Martin C; Unité Molécules de Communication et Adaptation des Microorganismes (MCAM, UMR 7245), Muséum national d'Histoire Naturelle, Paris 75005, France.
Hoerauf A; Unité Molécules de Communication et Adaptation des Microorganismes (MCAM, UMR 7245), Muséum national d'Histoire Naturelle, Paris 75005, France.
Hernandez G; Institute for Medical Microbiology, Immunology & Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Dalvie D; German Center for Infection Research (DZIF), partner site Bonn-Cologne, 53127 Bonn, Germany.
Specht S; Bristol Myers Squibb, San Diego, California 92121, United States.
Hübner MP; Bristol Myers Squibb, San Diego, California 92121, United States.
Scandale I; Institute for Medical Microbiology, Immunology & Parasitology, University Hospital Bonn, 53127 Bonn, Germany.

J Med Chem ; 65(16): 11388-11403, 2022 08 25.

Article en En | MEDLINE | ID: mdl-35972896

Asunto(s)

Filariasis Linfática; Oncocercosis; Adulto; Aminas; Humanos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_helminthiasis / 3_neglected_diseases / 3_onchocerciasis Asunto principal: Oncocercosis / Filariasis Linfática Límite: Adult / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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