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Increased Circulating CD62E+ Endothelial Extracellular Vesicles Predict Severity and in- Hospital Mortality of COVID-19 Patients.
Mezine, Fariza; Guerin, Coralie L; Philippe, Aurélien; Gendron, Nicolas; Soret, Lou; Sanchez, Olivier; Mirault, Tristan; Diehl, Jean-Luc; Chocron, Richard; Boulanger, Chantal M; Smadja, David M.
Afiliación
  • Mezine F; Université Paris Cité, INSERM, PARCC, F-75015, Paris, France.
  • Guerin CL; Cytometry core, Institut Curie, F-75005, Paris, France.
  • Philippe A; Université Paris Cité, INSERM, Innovative Therapies in Haemostasis, F-75006, Paris, France.
  • Gendron N; Université Paris Cité, INSERM, Innovative Therapies in Haemostasis, F-75006, Paris, France.
  • Soret L; Hematology department and Biosurgical research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, F-75015, Paris, France.
  • Sanchez O; Université Paris Cité, INSERM, Innovative Therapies in Haemostasis, F-75006, Paris, France.
  • Mirault T; Hematology department and Biosurgical research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, F-75015, Paris, France.
  • Diehl JL; Université Paris Cité, INSERM, Innovative Therapies in Haemostasis, F-75006, Paris, France.
  • Chocron R; Hematology department and Biosurgical research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, F-75015, Paris, France.
  • Boulanger CM; Université Paris Cité, INSERM, Innovative Therapies in Haemostasis, F-75006, Paris, France.
  • Smadja DM; Respiratory disease department and Biosurgical research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, F-75015, Paris, France.
Stem Cell Rev Rep ; 19(1): 114-119, 2023 01.
Article en En | MEDLINE | ID: mdl-35982357
COVID-19 and infectious diseases have been included in strategic development goals (SDG) of United Nations (UN). Severe form of COVID-19 has been described as an endothelial disease. In order to better evaluate Covid-19 endotheliopathy, we characterized several subsets of circulating endothelial extracellular vesicles (EVs) at hospital admission among a cohort of 60 patients whose severity of COVID-19 was classified at the time of inclusion. Degree of COVID-19 severity was determined upon inclusion and categorized as moderate to severe in 40 patients and critical in 20 patients. We measured citrated plasma EVs expressing endothelial membrane markers. Endothelial EVs were defined as harboring VE-cadherin (CD144+), PECAM-1 (CD31 + CD41-) or E-selectin (CD62E+). An increase in CD62E + EV levels on admission to the hospital was significantly associated with critical disease. Moreover, Kaplan-Meier survival curves for CD62E + EV level showed that level ≥ 88,053 EVs/µL at admission was a significant predictor of in hospital mortality (p = 0.004). Moreover, CD62E + EV level ≥ 88,053 EV/µL was significantly associated with higher in-hospital mortality (OR 6.98, 95% CI 2.1-26.4, p = 0.002) in a univariate logistic regression model, while after adjustment to BMI CD62E + EV level ≥ 88,053 EV/µL was always significantly associated with higher in-hospital mortality (OR 5.1, 95% CI 1.4-20.0, p = 0.01). The present findings highlight the potential interest of detecting EVs expressing E-selectin (CD62) to discriminate Covid-19 patients at the time of hospital admission and identify individuals with higher risk of fatal outcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vesículas Extracelulares / COVID-19 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Stem Cell Rev Rep Año: 2023 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vesículas Extracelulares / COVID-19 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Stem Cell Rev Rep Año: 2023 Tipo del documento: Article País de afiliación: Francia
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