Enantioselective Copper-Catalyzed sp2/sp3 Diborylation of 1-Chloro-1-Trifluoromethylalkenes.
ACS Cent Sci
; 8(8): 1134-1144, 2022 Aug 24.
Article
en En
| MEDLINE
| ID: mdl-36032759
Fluorine-containing organoboron compounds have emerged as novel building blocks in chemical synthesis; among them, fluorinated sp2/sp3 diborylated compounds are particularly appealing, since they might undergo chemoselective and diversified transformations of different C-B bonds with fluorinated functionality, thus bringing versatility and complexity to the eventual products. However, expedient, synthetic strategies for the construction of such fluorinated diborylative compounds are very sparse. Herein, we disclose enantioselective Cu-catalyzed sp2/sp3 diborylations of 1-chloro-1-trifluoromethylalkenes, leading to diborylated compounds bearing a gem-difluoroalkenyl moiety; most intriguingly, the new formed C-B bonds include one stereoselective and optically pure Csp3-B bond. Further transformations on the eventual products demonstrated the values of our presented strategy.
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01-internacional
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MEDLINE
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En
Revista:
ACS Cent Sci
Año:
2022
Tipo del documento:
Article
País de afiliación:
China