Transcriptomic Analysis of DNA Repair Pathways in Human Non-Small Cell Lung Cancer Cells Surviving Multifraction X-Ray Irradiation.
Bull Exp Biol Med
; 173(4): 454-458, 2022 Aug.
Article
en En
| MEDLINE
| ID: mdl-36058984
ABSTRACT
Radioresistant sublines of non-small cell lung cancer cells differing in the p53 status were obtained A549 (p53 wild type) and H1299 (p53 deficient). The exposure to ionizing radiation was carried out using a standard protocol developed on the basis of empirical clinical experience and consisting in exposure in a dose of 2 Gy once a day, 5 days a week up to total dose of 60 Gy. The cells survived after irradiation demonstrated reduced radiosensitivity, as well as changes in differential gene expression in comparison with parental cells. Some differences in the signaling pathways involved in DNA repair were revealed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma de Pulmón de Células no Pequeñas
/
Neoplasias Pulmonares
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2022
Tipo del documento:
Article
País de afiliación:
Rusia