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Zinc transporter Slc30a1 regulates melanocyte development by interacting with mt2 in zebrafish.
Xia, Zhidan; Yang, Xiu; Bi, Xinying; Tong, Xiujuan; Min, Junxia; Wang, Fudi.
Afiliación
  • Xia Z; The Fourth Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, People's Republic of China. Electronic address: xiazhidan@zju.edu.cn.
  • Yang X; The Fourth Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
  • Bi X; The Fourth Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
  • Tong X; The Fourth Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
  • Min J; The Fourth Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
  • Wang F; The Fourth Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, People's Republic of China. Electronic address: fwang@zju.edu.cn.
Eur J Cell Biol ; 101(4): 151272, 2022.
Article en En | MEDLINE | ID: mdl-36063588
The essential trace element zinc is involved in multiple biological processes including development and metabolism, while its role in melanocyte formation is still unclear. Slc30a1a and Slc30a1b are zinc exporters in zebrafish. Here, we found that melanocytes were increased in slc30a1a and slc30a1b double mutant zebrafish. SMART-seq data revealed that genes involved in the melanoma pathway and the gene mt2, which encodes zinc-binding protein, were significantly upregulated in the mutants. In addition, the expression of mt2 was specifically increased in mutant melanocytes, as detected by in situ hybridization, suggesting an essential role of this gene in the tissue. Mechanistically, we demonstrated that elevated zinc levels resulting from Slc30a1 deficiency promoted melanocyte proliferation and that mt2 played a protective role in the process of Slc30a1/zinc-mediated melanocyte hyperplasia. This study uncovered the critical function of Slc30a1-mediated zinc homeostasis in melanocyte development and suggests that accumulated zinc in melanocytes would be a risk for inducing melanoma and that mt2 is a potential target for controlling diseases related to abnormal melanocyte development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Melanoma Límite: Animals Idioma: En Revista: Eur J Cell Biol Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Melanoma Límite: Animals Idioma: En Revista: Eur J Cell Biol Año: 2022 Tipo del documento: Article
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