Characteristics and outcomes of COVID-19 in heart transplantation recipients in the Netherlands.
Neth Heart J
; 30(11): 519-525, 2022 Nov.
Article
en En
| MEDLINE
| ID: mdl-36074336
ABSTRACT
BACKGROUND:
Immunocompromised patients are at high risk of complicated severe acute respiratory coronavirus 2 infection. The aim of this retrospective study was to describe the characteristics and outcomes of heart transplantation (HTx) recipients with coronavirus disease 2019 (COVID-19) in the Netherlands.METHODS:
HTx patients from one of the three HTx centres in the Netherlands with COVID-19 (proven by positive reverse-transcription polymerase chain reaction or serology test result) between February 2020 and June 2021 were included. The primary endpoint was all-cause mortality and the secondary endpoint was disease severity.RESULTS:
COVID-19 was diagnosed in 54/665 HTx patients (8%), with a mean (±â¯standard deviation (SD)) time after HTx of 11⯱ 8 years. Mean (±â¯SD) age was 53⯱ 14 years and 39% were female. Immunosuppressive therapy dosage was reduced in 37% patients (20/54). Hospitalisation was required in 39% patients (21/54), and 13% patients (7/54) had severe COVID-19 (leading to intensive care unit (ICU) admission or death). In-hospital mortality was 14% (3/21), and all-cause mortality was 6%. Compared with patients with moderate COVID-19 (hospitalised without ICU indication), severe COVID-19 patients tended to be transplanted earlier and had a significantly higher mean (±â¯SD) body mass index (26⯱ 3 vs 30⯱ 3â¯kg/m2, pâ¯= 0.01). Myocardial infarction, cellular rejection and pulmonary embolism were observed once in three different HTx patients.CONCLUSION:
HTx patients were at increased risk of complicated COVID-19 with frequent hospitalisation, but the all-cause mortality was substantially lower than previously described (7-33%).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
4_TD
/
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
4_covid_19
/
6_venous_thromboembolic_disease
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Neth Heart J
Año:
2022
Tipo del documento:
Article
País de afiliación:
Países Bajos