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Impaired interhemispheric synchrony in Parkinson's disease patients with apathy.
Zhang, Heng; Shan, Ai-di; Gan, Cai-Ting; Zhang, Li; Wang, Li-Na; Sun, Hui-Min; Yuan, Yong-Sheng; Zhang, Ke-Zhong.
Afiliación
  • Zhang H; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Shan AD; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Gan CT; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Zhang L; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Wang LN; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Sun HM; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Yuan YS; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: da_sheng@126.com.
  • Zhang KZ; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: kezhong_zhang1969@126.com.
J Affect Disord ; 318: 283-290, 2022 12 01.
Article en En | MEDLINE | ID: mdl-36096372
BACKGROUND: Apathy is a common non-motor symptom in Parkinson's disease (PD), yet the neural mechanism remains unknown. It has been reported that the lateralization of dopamine levels is correlated with apathetic symptoms. We aimed to ascertain the role of lateralization in the neuropathogenesis of apathy in PD. METHODS: Twenty-six apathetic PD patients (PD-A), twenty-seven nonapathetic PD patients (PD-NA), and twenty-three healthy controls (HCs) were recruited. All subjects underwent T1-weighted and resting state functional MRI scanning during OFF medication state. Voxel-mirrored Homotopic Connectivity (VMHC) and asymmetry voxel-based morphometry (asymmetry VBM) analysis were applied to detect the synchrony of homotopic connections between hemispheres and grey matter asymmetry index. RESULTS: Compared with both PD-NA and HCs groups, the PD-A group showed excessively decreased z-VMHC values in the nucleus accumbens (NAcc) and putamen. Additionally, both PD subgroups exhibited decreased z-VMHC values in the cerebellum lobule VIII compared with controls. However, no corresponding alteration in grey matter asymmetry index was found. Further, a negative correlation between the z-VMHC values of the NAcc and the Apathy Scale (AS) was confirmed in the PD-A group. Meanwhile, the same relationship was also confirmed between the putamen and AS. Notably, ROC curve analyses uncovered that the z-VMHC values of the NAcc and putamen could be a potential neuroimaging feature discerning apathetic PD patient, respectively. LIMITATIONS: This is a cross-sectional study. CONCLUSION: Our findings demonstrated that the asymmetric functional connectivity in the mesocorticolimbic and nigrostriatal systems might induce the pathophysiological mechanisms of apathy in PD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Apatía Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Affect Disord Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Apatía Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Affect Disord Año: 2022 Tipo del documento: Article País de afiliación: China
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