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Effects of curcumin on low-density lipoprotein oxidation: From experimental studies to clinical practice.
Baratzadeh, Fatemeh; Butler, Alexandra E; Kesharwani, Prashant; Moallem, Seyed Adel; Sahebkar, Amirhossein.
Afiliación
  • Baratzadeh F; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Butler AE; Department of Clinical Pharmacy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Kesharwani P; Research Department, Royal College of Surgeons in Ireland, PO Box 15503, Adliya, Bahrain.
  • Moallem SA; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
  • Sahebkar A; Department of Pharmacology and Toxicology, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq.
EXCLI J ; 21: 840-851, 2022.
Article en En | MEDLINE | ID: mdl-36110563
ABSTRACT
Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxidative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: EXCLI J Año: 2022 Tipo del documento: Article País de afiliación: Irán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: EXCLI J Año: 2022 Tipo del documento: Article País de afiliación: Irán
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