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The Effect of PD-1 Inhibitor Combined with Chemotherapy on the Level of Peripheral Blood T Lymphocytes among Patients with Non-Small-Cell Lung Cancer and Its Relationship with Prognosis.
Zhao, Yun; He, Jianbo; Zhou, Shaozhang; Ning, Ruiling; Zhao, Wenhua; Wang, Huilin; Su, Cuiyun; Jiang, Wei; Zhong, Xiaoning; Yu, Qitao.
Afiliación
  • Zhao Y; Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
  • He J; Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
  • Zhou S; Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
  • Ning R; Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
  • Zhao W; Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
  • Wang H; Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
  • Su C; Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
  • Jiang W; Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
  • Zhong X; Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi, China.
  • Yu Q; Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
Comput Math Methods Med ; 2022: 1679191, 2022.
Article en En | MEDLINE | ID: mdl-36118825
Objective: To explore the effect of combined treatment of PD-1 inhibitor and chemotherapy on the level of peripheral blood T lymphocytes in non-small-cell lung cancer (NSCLC) patients and its relationship with prognosis. Methods: Retrospective analysis was conducted on 150 NSCLC patients treated in Guangxi Medical University Affiliated Tumor Hospital from June 2018 to September 2020, including 77 patients treated with PD-1 inhibitor combined with chemotherapy as the observation group (OG) and 73 patients with chemotherapy alone as the control group (CG). Therapeutic efficacy, immune function indexes, serum tumor markers, incidence of adverse reactions during hospitalization, 1-year survival rate, and life quality after 6 months of treatment were observed and compared between two groups. Results: Compared to the CG, the therapeutic effect of OG was evidently better. Six months after treatment, levels of CD4+/CD8+, NK cells, and CD4 + in two groups were elevated markedly, and indexes of OG were notably and comparatively higher than those in the other group. After treatment, OG was observed with a marked decline regarding levels of CYFRA21-1, CEA, and CA125 compared to those in the CG; and there was no notable difference in terms of adverse reaction occurrence between two groups, but the 1-year survival rate and 6-month life quality in OG over ranked those in CG. Conclusion: For NSCLC patients, the PD-1 inhibitor given on the basis of chemotherapy can further improve the clinical efficacy and improve immune function and long-term survival rate of patients on the premise of ensuring the safety of treatment, which is worth promoting in clinical practice.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_other_respiratory_diseases / 6_trachea_bronchus_lung_cancer Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Comput Math Methods Med Asunto de la revista: INFORMATICA MEDICA Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_other_respiratory_diseases / 6_trachea_bronchus_lung_cancer Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Comput Math Methods Med Asunto de la revista: INFORMATICA MEDICA Año: 2022 Tipo del documento: Article País de afiliación: China
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