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PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD.
Pilotto, Federica; Schmitz, Alexander; Maharjan, Niran; Diab, Rim; Odriozola, Adolfo; Tripathi, Priyanka; Yamoah, Alfred; Scheidegger, Olivier; Oestmann, Angelina; Dennys, Cassandra N; Sinha Ray, Shrestha; Rodrigo, Rochelle; Kolb, Stephen; Aronica, Eleonora; Di Santo, Stefano; Widmer, Hans Rudolf; Charlet-Berguerand, Nicolas; Selvaraj, Bhuvaneish T; Chandran, Siddharthan; Meyer, Kathrin; Zuber, Benoît; Goswami, Anand; Weis, Joachim; Saxena, Smita.
Afiliación
  • Pilotto F; Department of Neurology, Inselspital, University Hospital, Bern, Switzerland.
  • Schmitz A; Department for BioMedical Research, University of Bern, Bern, Switzerland.
  • Maharjan N; Department of Neurology, Inselspital, University Hospital, Bern, Switzerland.
  • Diab R; Department for BioMedical Research, University of Bern, Bern, Switzerland.
  • Odriozola A; Department of Neurology, Inselspital, University Hospital, Bern, Switzerland.
  • Tripathi P; Department for BioMedical Research, University of Bern, Bern, Switzerland.
  • Yamoah A; Department of Neurology, Inselspital, University Hospital, Bern, Switzerland.
  • Scheidegger O; Department for BioMedical Research, University of Bern, Bern, Switzerland.
  • Oestmann A; Institute of Anatomy, University of Bern, Bern, Switzerland.
  • Dennys CN; Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.
  • Sinha Ray S; Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.
  • Rodrigo R; Department of Neurology, Inselspital, University Hospital, Bern, Switzerland.
  • Kolb S; Department of Neurology, Inselspital, University Hospital, Bern, Switzerland.
  • Aronica E; Department for BioMedical Research, University of Bern, Bern, Switzerland.
  • Di Santo S; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
  • Widmer HR; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
  • Charlet-Berguerand N; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
  • Selvaraj BT; Department of Neurology and Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA.
  • Chandran S; Department of (Neuro) Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
  • Meyer K; Department of Neurosurgery, Inselspital, University Hospital, Bern, Switzerland.
  • Zuber B; Department of Neurosurgery, Inselspital, University Hospital, Bern, Switzerland.
  • Goswami A; CNRS, Inserm, IGBMC UMR 7104, U 1258, Université de Strasbourg, F-67404, Illkirch, France.
  • Weis J; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh, EH16 4SB, UK.
  • Saxena S; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, EH16 4SB, UK.
Acta Neuropathol ; 144(5): 939-966, 2022 11.
Article en En | MEDLINE | ID: mdl-36121477
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_alzheimer_other_dementias / 6_endocrine_disorders / 6_mental_health_behavioral_disorders Asunto principal: Demencia Frontotemporal / Estrés del Retículo Endoplásmico / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: Acta Neuropathol Año: 2022 Tipo del documento: Article País de afiliación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_alzheimer_other_dementias / 6_endocrine_disorders / 6_mental_health_behavioral_disorders Asunto principal: Demencia Frontotemporal / Estrés del Retículo Endoplásmico / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: Acta Neuropathol Año: 2022 Tipo del documento: Article País de afiliación: Suiza