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Hypoxylonone, a new oxa-bridged seven-membered ring analog from fungus Hypoxylon cf. subgilvum SWUF15-004.
Jantaharn, Phongphan; Mongkolthanaruk, Wiyada; Suwannasai, Nuttika; Senawong, Thanaset; Boonmak, Jaursup; Youngme, Sujittra; McCloskey, Sirirath.
Afiliación
  • Jantaharn P; Natural Products Research Unit, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Mongkolthanaruk W; Department of Microbiology, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Suwannasai N; Department of Biology, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand.
  • Senawong T; Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Boonmak J; Materials Chemistry Research Center, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Youngme S; Materials Chemistry Research Center, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • McCloskey S; Natural Products Research Unit, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Nat Prod Res ; : 1-8, 2022 Sep 20.
Article en En | MEDLINE | ID: mdl-36125412
ABSTRACT
A new oxa-bridged seven-membered ring analog, hypoxylonone (1), and thirteen known compounds (2-14) were isolated from fungus Hypoxylon cf. subgilvum SWUF15-004. The structures were elucidated by the analysis of spectroscopic (IR, 1 D and 2 D NMR), HRESIMS and X-ray diffraction (MoKα) data. Several isolated compounds were evaluated for cytotoxicity against four human cancer cell lines (HeLa, HT29, MCF-7, A549). Compound 1 exhibited weak inhibitory effects of the nitric oxide production in RAW264.7 cells. Compounds 8 and 9 exhibited slight cytotoxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2022 Tipo del documento: Article País de afiliación: Tailandia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2022 Tipo del documento: Article País de afiliación: Tailandia