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Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development.
Page, Natalie; Wappett, Mark; O'Dowd, Colin R; O'Rourke, Martin; Gavory, Gerald; Zhang, Lixin; Rountree, J S Shane; Jordan, Linda; Barker, Oliver; Gibson, Hayley; Boyd, Caroline; Feutren-Burton, Stephanie; McLean, Estelle; Trevitt, Graham; Harrison, Timothy.
Afiliación
  • Page N; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
  • Wappett M; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
  • O'Dowd CR; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
  • O'Rourke M; Amphista Therapeutics, BioCity, Bo'Ness Rd, Newhouse, Chapelhall, Motherwell, ML1 5UH, UK.
  • Gavory G; Ridgeline Therapeutics GmbH, Technologiepark, Hochbergerstrasse 60C, 4057, Basel, Switzerland.
  • Zhang L; Shenyang University of Chemical Technology, Shenyang, China.
  • Rountree JSS; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
  • Jordan L; Globachem, Alderley Park, 2 BioHub, Mereside, Macclesfield, SK10 4TG, UK.
  • Barker O; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
  • Gibson H; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
  • Boyd C; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
  • Feutren-Burton S; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
  • McLean E; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
  • Trevitt G; Sygnature Discovery, BioCity, Pennyfoot Street, Nottingham, NG1 1GR, UK.
  • Harrison T; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK. timothy.harrison@almacgroup.com.
Sci Rep ; 12(1): 15715, 2022 09 20.
Article en En | MEDLINE | ID: mdl-36127435
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido