The Role of Heme Peroxo Oxidants in the Rational Mechanistic Modeling of Nitric Oxide Synthase: Characterization of Key Intermediates and Elucidation of the Mechanism.

Mondal, Pritam; Ishigami, Izumi; Yeh, Syun-Ru; Wijeratne, Gayan B

Mondal, Pritam; Ishigami, Izumi; Yeh, Syun-Ru; Wijeratne, Gayan B.

Afiliación

Mondal P; Department of Chemistry and O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Ishigami I; Department of Physiology and Biophysics, Albert Einstein College of Medicine, The Bronx, NY 10461, USA.
Yeh SR; Department of Physiology and Biophysics, Albert Einstein College of Medicine, The Bronx, NY 10461, USA.
Wijeratne GB; Department of Chemistry and O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35205, USA.

Angew Chem Int Ed Engl ; 61(48): e202211521, 2022 11 25.

Article en En | MEDLINE | ID: mdl-36169890

Asunto(s)

Hemo; Oxidantes; Humanos; Animales; Hemo/química; Óxido Nítrico Sintasa/química; Óxido Nítrico Sintasa/metabolismo; Oxidación-Reducción; Oximas; Óxido Nítrico; Mamíferos/metabolismo

Palabras clave

Bioinorganic Chemistry; Enzyme Models; Heme Peroxo Complexes; Heme Proteins; Structure-Activity Relationships

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidantes / Hemo Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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