Sequencing Mycobacteria and Algorithm-determined Resistant Tuberculosis Treatment (SMARTT): a study protocol for a phase IV pragmatic randomized controlled patient management strategy trial.

Van Rie, Annelies; De Vos, Elise; Costa, Emilyn; Verboven, Lennert; Ndebele, Felex; Heupink, Tim H; Abrams, Steven; Fanampe, Boitumelo; Van der Spoel Van Dyk, Anneke; Charalambous, Salome; Churchyard, Gavin; Warren, Rob

Van Rie, Annelies; De Vos, Elise; Costa, Emilyn; Verboven, Lennert; Ndebele, Felex; Heupink, Tim H; Abrams, Steven; Fanampe, Boitumelo; Van der Spoel Van Dyk, Anneke; Charalambous, Salome; Churchyard, Gavin; Warren, Rob.

Afiliación

Van Rie A; Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. annelies.vanrie@uantwerpen.be.
De Vos E; Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Costa E; South African Medical Research Council Centre for Tuberculosis Research, DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Verboven L; Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Ndebele F; Aurum Institute, Johannesburg, South Africa.
Heupink TH; Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Abrams S; Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Fanampe B; Free State Department of Health, Bloemfontein, South Africa.
Van der Spoel Van Dyk A; Universitas Academic Laboratory, National Health Laboratory Service and Department of Medical Microbiology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Charalambous S; Aurum Institute, Johannesburg, South Africa.
Churchyard G; Aurum Institute, Johannesburg, South Africa.
Warren R; South African Medical Research Council Centre for Tuberculosis Research, DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Trials ; 23(1): 864, 2022 Oct 08.

Article en En | MEDLINE | ID: mdl-36209235

Asunto(s)

Mycobacterium; Tuberculosis Resistente a Múltiples Medicamentos; Algoritmos; Antituberculosos/efectos adversos; Ensayos Clínicos Fase IV como Asunto; Humanos; Recurrencia Local de Neoplasia; Ensayos Clínicos Pragmáticos como Asunto; Ensayos Clínicos Controlados Aleatorios como Asunto; Rifampin/efectos adversos; Tuberculosis Resistente a Múltiples Medicamentos/diagnóstico; Tuberculosis Resistente a Múltiples Medicamentos/tratamiento farmacológico

Palabras clave

Clinical trial; Drug resistance; Pragmatic; Strategy trial; Treatment recommender; Tuberculosis; Whole-genome sequencing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 / 3_ND Problema de salud: 1_doencas_nao_transmissiveis / 1_doencas_transmissiveis / 2_cobertura_universal / 2_enfermedades_transmissibles / 2_muertes_prematuras_enfermedades_notrasmisibles / 3_neglected_diseases / 3_tuberculosis Asunto principal: Tuberculosis Resistente a Múltiples Medicamentos / Mycobacterium Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: Bélgica

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