Therapeutic targeting of glutamate dehydrogenase 1 that links metabolic reprogramming and Snail-mediated epithelial-mesenchymal transition in drug-resistant lung cancer.

Wang, Qizhi; Wu, Ming; Li, Haobin; Rao, Xin; Ao, Luyao; Wang, Huan; Yao, Lan; Wang, Xinyu; Hong, Xiaodan; Wang, Jun; Aa, Jiye; Sun, Minjie; Wang, Guangji; Liu, Jiali; Zhou, Fang

Wang, Qizhi; Wu, Ming; Li, Haobin; Rao, Xin; Ao, Luyao; Wang, Huan; Yao, Lan; Wang, Xinyu; Hong, Xiaodan; Wang, Jun; Aa, Jiye; Sun, Minjie; Wang, Guangji; Liu, Jiali; Zhou, Fang.

Afiliación

Wang Q; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China.
Wu M; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China.
Li H; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China.
Rao X; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China.
Ao L; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China.
Wang H; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China.
Yao L; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China; National Drug Clinical trial Institute, The Second Affiliated H
Wang X; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China.
Hong X; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China.
Wang J; Department of Thoracic Surgery, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210009, China.
Aa J; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China.
Sun M; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China.
Wang G; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China. Electronic address: guangjiwang@hotmail.com.
Liu J; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China. Electronic address: Carrie_CPU@hotmail.com.
Zhou F; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang #24, Nanjing, Jiangsu 210009, China. Electronic address: zf1113@163.com.

Pharmacol Res ; 185: 106490, 2022 11.

Article en En | MEDLINE | ID: mdl-36216131

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas; Neoplasias Pulmonares; Humanos; Carcinoma de Pulmón de Células no Pequeñas/patología; Línea Celular Tumoral; Resistencia a Antineoplásicos/genética; Transición Epitelial-Mesenquimal; Glutamato Deshidrogenasa/genética; Glutamato Deshidrogenasa/uso terapéutico; Glutamina/metabolismo; Glutamina/uso terapéutico; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patología; Factores de Transcripción de la Familia Snail/metabolismo

Palabras clave

Drug resistance; Epithelialmesenchymal transition; Glutamate dehydrogenase 1; Glutamine catabolism; Metabolic reprogramming

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China

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