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Potential therapeutic targets for age-related macular degeneration: The nuclear option.
Choudhary, Mayur; Malek, Goldis.
Afiliación
  • Choudhary M; Duke Eye Center, Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
  • Malek G; Duke Eye Center, Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA; Department of Pathology, Duke University School of Medicine, Durham, NC, USA. Electronic address: gmalek@duke.edu.
Prog Retin Eye Res ; 94: 101130, 2023 05.
Article en En | MEDLINE | ID: mdl-36220751
ABSTRACT
The functions and activities of nuclear receptors, the largest family of transcription factors in the human genome, have classically focused on their ability to act as steroid and hormone sensors in endocrine organs. However, they are responsible for a diverse array of physiological functions, including cellular homeostasis and metabolism, during development and aging. Though the eye is not a traditional endocrine organ, recent studies have revealed high expression levels of nuclear receptors in cells throughout the posterior pole. These findings have precipitated an interest in investigating the role of these transcription factors in the eye as a function of age and ocular disease, in particular age-related macular degeneration (AMD). As the leading cause of vision impairment in the elderly, identifying signaling pathways that may be targeted for AMD therapy is of great importance, given the lack of therapeutic options for over 85% of patients with this disease. Herein we review this relatively new field and recent findings supporting the hypothesis that the eye is a secondary endocrine organ, in which nuclear receptors serve as the bedrock for biological processes in cells vulnerable in AMD, including retinal pigment epithelial and choroidal endothelial cells, and discuss the therapeutic potential of targeting these receptors for AMD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Endoteliales / Degeneración Macular Tipo de estudio: Prognostic_studies Límite: Aged / Humans Idioma: En Revista: Prog Retin Eye Res Asunto de la revista: OFTALMOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Endoteliales / Degeneración Macular Tipo de estudio: Prognostic_studies Límite: Aged / Humans Idioma: En Revista: Prog Retin Eye Res Asunto de la revista: OFTALMOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
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