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Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.
McBride, Christopher; Trzoss, Lynnie; Povero, Davide; Lazic, Milos; Ambrus-Aikelin, Geza; Santini, Angelina; Pranadinata, Rama; Bain, Gretchen; Stansfield, Ryan; Stafford, Jeffrey A; Veal, James; Takahashi, Ryan; Ly, Justin; Chen, Shu; Liu, Liling; Nespi, Marika; Blake, Robert; Katewa, Arna; Kleinheinz, Tracy; Sujatha-Bhaskar, Swathi; Ramamoorthi, Nandhini; Sims, Jessica; McKenzie, Brent; Chen, Mark; Ultsch, Mark; Johnson, Matthew; Murray, Jeremy; Ciferri, Claudio; Staben, Steven T; Townsend, Michael J; Stivala, Craig E.
Afiliación
  • McBride C; Jecure Therapeutics, San Diego, California 92121, United States.
  • Trzoss L; Jecure Therapeutics, San Diego, California 92121, United States.
  • Povero D; Jecure Therapeutics, San Diego, California 92121, United States.
  • Lazic M; Jecure Therapeutics, San Diego, California 92121, United States.
  • Ambrus-Aikelin G; Jecure Therapeutics, San Diego, California 92121, United States.
  • Santini A; Jecure Therapeutics, San Diego, California 92121, United States.
  • Pranadinata R; Jecure Therapeutics, San Diego, California 92121, United States.
  • Bain G; Jecure Therapeutics, San Diego, California 92121, United States.
  • Stansfield R; Jecure Therapeutics, San Diego, California 92121, United States.
  • Stafford JA; Jecure Therapeutics, San Diego, California 92121, United States.
  • Veal J; Jecure Therapeutics, San Diego, California 92121, United States.
  • Takahashi R; Genentech Inc., South San Francisco, California 94080, United States.
  • Ly J; Genentech Inc., South San Francisco, California 94080, United States.
  • Chen S; Genentech Inc., South San Francisco, California 94080, United States.
  • Liu L; Genentech Inc., South San Francisco, California 94080, United States.
  • Nespi M; Genentech Inc., South San Francisco, California 94080, United States.
  • Blake R; Genentech Inc., South San Francisco, California 94080, United States.
  • Katewa A; Genentech Inc., South San Francisco, California 94080, United States.
  • Kleinheinz T; Genentech Inc., South San Francisco, California 94080, United States.
  • Sujatha-Bhaskar S; Genentech Inc., South San Francisco, California 94080, United States.
  • Ramamoorthi N; Genentech Inc., South San Francisco, California 94080, United States.
  • Sims J; Genentech Inc., South San Francisco, California 94080, United States.
  • McKenzie B; Genentech Inc., South San Francisco, California 94080, United States.
  • Chen M; Genentech Inc., South San Francisco, California 94080, United States.
  • Ultsch M; Genentech Inc., South San Francisco, California 94080, United States.
  • Johnson M; Genentech Inc., South San Francisco, California 94080, United States.
  • Murray J; Genentech Inc., South San Francisco, California 94080, United States.
  • Ciferri C; Genentech Inc., South San Francisco, California 94080, United States.
  • Staben ST; Genentech Inc., South San Francisco, California 94080, United States.
  • Townsend MJ; Genentech Inc., South San Francisco, California 94080, United States.
  • Stivala CE; Genentech Inc., South San Francisco, California 94080, United States.
J Med Chem ; 65(21): 14721-14739, 2022 11 10.
Article en En | MEDLINE | ID: mdl-36279149
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxazinas / Proteína con Dominio Pirina 3 de la Familia NLR Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxazinas / Proteína con Dominio Pirina 3 de la Familia NLR Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos