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The association of cervicovaginal Langerhans cells with clearance of human papillomavirus.
Dai, Wenkui; Gui, Liming; Du, Hui; Li, Shuaicheng; Wu, Ruifang.
Afiliación
  • Dai W; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
  • Gui L; Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center (PKU-HKUST) Medical Center, Shenzhen, China.
  • Du H; Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, China.
  • Li S; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
  • Wu R; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
Front Immunol ; 13: 918190, 2022.
Article en En | MEDLINE | ID: mdl-36311788
ABSTRACT
Human papillomavirus (HPV) clearance is important in eliminating cervical cancer which contributes to high morbidity and mortality in women. Nevertheless, it remains largely unknown about key players in clearing pre-existing HPV infections. HPV antigens can be detected by the most important cervical antigen-presenting cells (Langerhans cells, LCs), of which the activities can be affected by cervicovaginal microbiota. In this review, we first introduce persistent HPV infections and then describe HPV-suppressed LCs activities, including but not limited to antigen uptake and presentation. Given specific transcriptional profiling of LCs in cervical epithelium, we also discuss the impact of cervicovaginal microbiota on LCs activation as well as the promise of exploring key microbial players in activating LCs and HPV-specific cellular immunity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 2_enfermedades_transmissibles / 6_cervical_cancer Asunto principal: Infecciones por Papillomavirus / Alphapapillomavirus Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 2_enfermedades_transmissibles / 6_cervical_cancer Asunto principal: Infecciones por Papillomavirus / Alphapapillomavirus Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: China
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