Modeling of Chronic Lung Inflammation in Rats by Repeated Intratracheal Administration of LPS.
Bull Exp Biol Med
; 173(6): 790-793, 2022 Oct.
Article
en En
| MEDLINE
| ID: mdl-36322314
ABSTRACT
A model of a chronic lung inflammation in SPF Sprague-Dawley rats was developed by repeated intratracheal administration of LPS in a dose of 0.4 mg/kg. On day 22 of the study, male rats treated with LPS have relative monocytopenia and reduced mean concentration of hemoglobin in the erythrocyte and the mean platelet volume in comparison with the control animals (saline). Intratracheal administration of LPS induced an inflammatory process in the lungs characterized by focal atelectasis, compensatory emphysematous expansion of subpleural pulmonary acini, focal mononuclear and neutrophilic perivascular and peribronchial infiltration, and minor focal mononuclear and neutrophilic infiltration of the alveolar walls. Against the background of LPS administration, germinal centers appeared in the lymphoid follicles of the white pulp of the spleen, and focal mononuclear infiltration of the tracheal mucosa and/or submucosa was observed in some animals.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
4_TD
Problema de salud:
4_pneumonia
Asunto principal:
Neumonía
/
Lipopolisacáridos
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2022
Tipo del documento:
Article
País de afiliación:
Rusia