A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein.

Bhat, Divya S; Spies, M Ashley; Spies, Maria

Bhat, Divya S; Spies, M Ashley; Spies, Maria.

Afiliación

Bhat DS; Department of Biochemistry, University of Iowa Carver College of Medicine, 51 Newton Road, Iowa City, IA 52242, USA.
Spies MA; Department of Biochemistry, University of Iowa Carver College of Medicine, 51 Newton Road, Iowa City, IA 52242, USA; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, The University of Iowa, Iowa City, Iowa 52242, USA.
Spies M; Department of Biochemistry, University of Iowa Carver College of Medicine, 51 Newton Road, Iowa City, IA 52242, USA. Electronic address: maria-spies@uiowa.edu.

DNA Repair (Amst) ; 120: 103421, 2022 12.

Article en En | MEDLINE | ID: mdl-36327799

Asunto(s)

Proteína BRCA2; Neoplasias Ováricas; Humanos; Femenino; Proteína Recombinante y Reparadora de ADN Rad52/genética; Proteína Recombinante y Reparadora de ADN Rad52/metabolismo; Proteína BRCA2/genética; Proteína BRCA2/metabolismo; Proteína BRCA1/metabolismo; Reparación del ADN; Neoplasias Ováricas/genética; Descubrimiento de Drogas; Relación Estructura-Actividad

Palabras clave

BRCA1; BRCA2; DNA double strand break repair; Homologous recombination; Pharmacological inhibition of protein-DNA interactions; RAD52; Synthetic lethality in cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Proteína BRCA2 Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: DNA Repair (Amst) Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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