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TREML4 polymorphisms increase the mRNA in blood leukocytes in the progression of atherosclerosis.
Duarte, Victor Hugo Rezende; Cruz, Marina Sampaio; Bertolami, Adriana; Hirata, Mario Hiroyuki; Hirata, Rosario Dominguez Crespo; Luchessi, André Ducati; Silbiger, Vivian Nogueira.
Afiliación
  • Duarte VHR; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, 59012-570, Brazil. victorhugorezendeduarte@gmail.com.
  • Cruz MS; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, 59012-570, Brazil.
  • Bertolami A; Dyslipidemia Medical Section, Dante Pazzanese Institute of Cardiology, Av. Dr. Dante Pazzanese, 500, São Paulo, 04012-909, Brazil.
  • Hirata MH; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, 580 B17 Lineu Prestes Av., Butantan, São Paulo, 05508-900, Brazil.
  • Hirata RDC; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, 580 B17 Lineu Prestes Av., Butantan, São Paulo, 05508-900, Brazil.
  • Luchessi AD; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, 59012-570, Brazil.
  • Silbiger VN; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, 59012-570, Brazil. vivian.silbiger@ufrn.br.
Sci Rep ; 12(1): 18612, 2022 11 03.
Article en En | MEDLINE | ID: mdl-36329152
ABSTRACT
TREML4 and other members of the triggering receptor expressed in the myeloid cell family are associated with a risk of atherosclerosis and progression in coronary artery disease, acute coronary syndrome, and coronary artery calcification. Herein, the relationship between TREML4 expression and its polymorphisms (rs2803495 and rs280396) was evaluated in patients with subclinical atherosclerosis (n = 340) and heart failure post-acute myocardial infarction (MI) (n = 68) for the first time. TREML4 variants rs2803495 (A > G) and rs2803496 (T > C) and leukocyte mRNA expression was analyzed by qRT-PCR. The rs2803495 G allele was associated with TREML4 expression (OR 8.01, CI 3.78-16.99, p < 0.001). Patients carrying the rs2803496 C minor allele (TC/CC genotypes) were more likely to express TREML4 than those without the C allele (OR 10.42, CI 4.76-22.78, p < 0.001), as well as having higher levels of TREML4 expression (OR 4.88, CI 2.35-10.12, p < 0.001). Thus, we report for the first time that TREML4 is not associated with the early stages of atherosclerotic plaque formation and later stages after MI. In conclusion, TREML4 mRNA expression in blood leukocytes is influenced by minor alleles (G and C) and may regulate differently during the atherosclerosis progression stages, but not in asymptomatic atherosclerosis disease and post-MI.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Aterosclerosis / Infarto del Miocardio Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Aterosclerosis / Infarto del Miocardio Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Brasil
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