The Impact of Highly Effective Modulator Therapy on Cystic Fibrosis Microbiology and Inflammation.
Clin Chest Med
; 43(4): 647-665, 2022 12.
Article
en En
| MEDLINE
| ID: mdl-36344072
ABSTRACT
Highly effective cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulator therapy (HEMT) corrects the underlying molecular defect causing CF disease. HEMT decreases symptom burden and improves clinical metrics and quality of life for most people with CF (PwCF) and eligible cftr mutations. Improvements in measures of pulmonary health suggest that restoration of function of defective CFTR anion channels by HEMT not only enhances airway mucociliary clearance, but also reduces chronic pulmonary infection and inflammation. This article reviews the evidence for how HEMT influences the dynamic and interdependent processes of infection and inflammation in the CF airway, and what questions remain unanswered.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinolonas
/
Fibrosis Quística
Aspecto:
Patient_preference
Límite:
Humans
Idioma:
En
Revista:
Clin Chest Med
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos