Glycosidase activated prodrugs for targeted cancer therapy.
Chem Soc Rev
; 51(23): 9694-9716, 2022 Nov 28.
Article
en En
| MEDLINE
| ID: mdl-36349720
ABSTRACT
In this review glycosidase activated prodrugs that target cancer cells are discussed. Glycosylated prodrugs undergo enzymatic bioconversion, cleaving the prodrug to release the anticancer drug at the desired site of action, hence minimising the toxic side effects associated with many current anticancer drugs. In addition, the presence of the carbohydrate moiety increases the aqueous solubility of the drugs, allowing for a more effective treatment. In the past decade, significant advancements have been made in this field that have led to the development of many novel carbohydrate-based prodrugs - ranging from simple glycoconjugates to complex self-assemblies and materials, which are discussed in detail herein.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Profármacos
/
Neoplasias
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Chem Soc Rev
Año:
2022
Tipo del documento:
Article
País de afiliación:
Irlanda